Symbol
Name
ID

Notch1
notch 1
MGI:97363

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Leukopenia	Splenomegaly	Hypersplenism
Disease(s) Associated with NOTCH1
Adams-Oliver syndrome

Mouse Phenotypes

aortic valve inflammation

increased T cell apoptosis

abnormal thymus morphology

abnormal thymus cell ratio

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal B cell differentiation

increased immature B cell number

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell receptor beta chain V(D)J recombination

decreased double-negative T cell number

decreased double-positive T cell number

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

increased single-positive T cell number

increased leukocyte cell number

abnormal B cell morphology

abnormal spleen morphology

chronic liver inflammation

Availability

Mouse Genotype

Notch1^tm2Pst/Notch1^tm2Pst

Notch1^tm1Con/Notch1⁺

Tg(LckNotch1)9Erob/?

Notch1^tm1Agt/Notch1^tm1Agt
Tg(Mx1-cre)1Cgn/0 (conditional)

Cpa3^tm3(icre)Hrr/Cpa3⁺
Notch1^tm1Agt/Notch1^tm1Agt (conditional)

Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Notch1^tm2Rko/Notch1^tm3(cre)Rko (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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